Texas Medical Office · San Antonio · HQ
San Antonio medical office space for lease.
What's available, what it costs, and how CRECO works the market.
In short: San Antonio’s medical office market is anchored by the South Texas Medical Center, one of the largest medical concentrations in the country, and by suburban clinics following population growth in the northwest, north, and I-35 corridors. Vacancy is lower than general office, and buildout cost and timing often matter more than rent.
Full-Service Brokerage
Who CRECO represents in San Antonio
CRECO represents tenants, landlords, owners, and investors — for lease and for sale — across retail (including restaurant space and pad sites), office (including medical office), industrial, flex, and land.
Tenants & buyers
Businesses leasing or buying retail, restaurant, office, medical office, industrial, or flex space in San Antonio — site selection, negotiation, and lease or purchase execution. Tenant rep is typically paid by the landlord.
Landlords & owners
Owners leasing or selling commercial property and land in San Antonio — pricing, marketing, tenant and buyer sourcing, negotiation, and property management.
Sellers & investors
Investment sales and acquisitions, 1031 exchange replacement property, and hold/sell analysis for commercial investors in San Antonio and across Texas.
Intermediary, when authorized
When both parties authorize it in writing, CRECO can act as an intermediary between landlord and tenant or seller and buyer, as Texas law permits.
Key takeaways
- Medical office is tighter than general office in San Antonio, and the best-located space near hospitals leases early.
- Tenant improvement terms often matter more than the base rent, because medical buildouts are expensive.
- Suburban clinics are expanding along the growth corridors, and primary care and dental often prefer ground-floor, high-visibility space.
- Many general office or retail spaces can convert to medical use if the building, parking, and landlord allow it.
Market Context
The San Antonio medical office market today.
San Antonio has one of the largest medical employment bases in the country, centered on the South Texas Medical Center. Specialists, imaging groups, and ancillary practices cluster around the hospitals, which keeps nearby medical office buildings competitive.
As the metro grows, primary care, urgent care, dental, and specialty groups follow rooftops into Stone Oak, the northwest corridor, and the I-35 northeast and southwest growth paths. These practices often prefer easy access, visible signage, and parking close to the door.
For a practice, the lease economics depend on what the landlord will contribute to the buildout and how long the term runs. A broker who understands medical plumbing, power, and compliance requirements can prevent expensive surprises, and can identify which spaces are already built out.
Where to Look
San Antonio medical office submarkets we cover.
South Texas Medical Center
Hospital-adjacent
The densest concentration of specialists and medical office buildings, with the tightest space.
Stone Oak / North
Affluent suburban clinics
Primary care, dental, and specialty practices serving a high-income trade area.
Northwest / Alamo Ranch
Growth corridor
New clinics following rooftop growth along US-90 and the 1604 loop.
Hill Country (Boerne / Fair Oaks Ranch)
Small-suite medical
Smaller practices serving affluent Hill Country households.
CRECO Approach
How we work San Antonio medical office deals.
CRECO is headquartered in the San Antonio region and represents tenants, landlords, and investors. For medical tenants, we define the program, survey buildings, and negotiate rent, improvement allowances, and term.
For owners of medical buildings, we market vacancies to practice groups, advise on pricing, and handle sale or recapitalization when the time is right.
Why CRECO for San Antonio medical office.
- Experience with medical buildouts and allowance negotiation
- Coverage from the Medical Center to the Hill Country
- Tenant, landlord, and investment representation under one roof
- Direct access to the broker handling your deal
Available Now
San Antonio medical office listings represented by CRECO
Live CRECO inventory for medical office space in the San Antonio area. Tenant-rep clients also get access to every other option on the market.
| Property | Type | Size | Price / rate |
|---|---|---|---|
| 2727 Mossrock 2727 Mossrock, San Antonio, TX 78230 | Office · For Lease | 14,000 SF | Contact for pricing |
| 8026 Vantage Dr 8026 Vantage Dr, San Antonio, TX 78230 | Office · For Lease | 28,294 SF | Contact for pricing |
| 7830 Louis Pasteur 7830 Louis Pasteur, San Antonio, TX 78229 | Medical Office · For Lease | 2,760 SF | Contact for pricing |
Zachary Stovall is as straight shooting and upstanding a person as you will find. I definitely recommend you use him for any of your commercial property management needs.
Trip Worden
Review on Google
Mr. Stovall and team are stand up people that do what they say they will do! They are knowledgeable and very capable of assisting you with your commercial property needs.
Michael Stuart
Local Guide · Review on Google
“Great company.”
San Antonio medical office
Looking for medical office space in San Antonio?
Tell us your size and timing and our team will send matching San Antonio medical office options — including space that is not publicly listed.
Zack Stovall (Broker) & Brian Blanco (Director of Leasing) — one of us replies personally
5.0 on Google · 38 reviewsFAQ
San Antonio medical office space — FAQ
What are current medical office lease rates and vacancy in San Antonio?
What medical office space is available in San Antonio right now?
Which San Antonio submarkets are best for medical office space?
Does CRECO represent tenants or landlords for San Antonio medical office deals?
How do I contact CRECO about medical office space in San Antonio?
Leasing, buying, or selling medical office property in San Antonio?
Tenants: we filter the market to the 4-5 properties worth a tour, typically at no cost to you. Owners and investors: we lease and sell medical office property in San Antonio.
Send me medical office optionsSources & methodology
Market figures on this page — rents, vacancy, absorption, cap rates, pricing, and inventory — are CRECO market estimates, as of November 2026. They are not attributed to a third-party research provider or data service, have not been independently verified, and are approximate; published market reports may differ. For current figures on a specific property or submarket, talk to our team at (210) 817-3443 or info@crecotx.com.